[IBU] IBU Digest, Vol 39, Issue 7

[Matt Braafhart]

SWEET!

Drink it up...

On Tue, Jun 10, 2008 at 12:00 PM, <ibu-request at iowabrewersunion.org> wrote:

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> Today's Topics:
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>   1. Resveratrol in Hops - Powerful antioxidants - Transgenic
>      research (Lenderts, Brian)
>
>
> ----------------------------------------------------------------------
>
> Message: 1
> Date: Mon, 9 Jun 2008 13:40:26 -0500
> From: "Lenderts, Brian" <brian.lenderts at pioneer.com>
> Subject: [IBU] Resveratrol in Hops - Powerful antioxidants -
>        Transgenic      research
> To: ibu <ibu at iowabrewersunion.org>
> Message-ID:
>        <3324986C923B8E418A89BB0928E2CF9AD528A317 at jhms31.phibred.com>
> Content-Type: text/plain; charset="us-ascii"
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>
> http://pubs.acs.org/cgi-bin/article.cgi/jafcau/2007/55/i17/html/jf070509e.html
>
> Time to live forever and drink beer for all of the ideal health benefits!
>
> Constitutive Expression of a Grapevine Stilbene Synthase Gene in Transgenic
> Hop (Humulus lupulus L.) Yields Resveratrol and Its Derivatives in
> Substantial Quantities
> Resveratrol, a well-known phytoalexin and antioxidant, is produced by the
> action of stilbene synthase (STS) in some plant species. Hop (Humulus
> lupulus L.) plants of the Tettnang variety were transformed with a gene
> encoding for STS from grapevine. Under the control of the constitutive 35S
> cauliflower mosaic virus promoter, expression of the transgene resulted in
> accumulation of resveratrol and high levels of its glycosylated derivatives
> in leaves and inflorescences. Piceid, the predominant derivative, reached a
> concentration of up to 560 [cid:image001.gif at 01C8CA36.12D47F60] g/g of
> fresh weight (f.w.) in hop cones, whereas no stilbenes were detected in
> nontransformed controls (wild-type). In transgenic plants the amounts of -
> and -acids, naringenin chalcone, and prenylated flavonoids did not change
> significantly when compared with nontransformed plants. Transgenic plants
> showed normal morphology and flower development as did the nontransformed
> controls. The results clearly sh
>  ow that in hop constitutive expression of sts interferes neither with
> plant development nor with the biosynthesis of secondary metabolites
> relevant for the brewing industry. Since resveratrol is a well-known
> phytoalexin and antioxidant, sts transgenic hop plants could display
> enhanced pathogen resistance against microbial pathogens, exhibit new
> beneficial properties for health, and open new venues for metabolic
> engineering.
>
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> End of IBU Digest, Vol 39, Issue 7
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